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The article from this special issue was previously published in Chirality, Volume 25, Issue 11, 2013. For completeness we are including the title page of the article in the following page, showing the original publication details. The full text of the article can be read in Issue 25:11 on Wiley Online Library: http://onlinelibrary.wiley.com/doi/10.1002/chir.22214/full
A comparative enantioselective analysis using immobilized amylose tris‐(3‐chlorophenylcarbamate) as chiral stationary phase in conventional high‐performance liquid chromatography (HPLC) with Chiralpak ID (4.6 mm ID × 250 mm, 5 µm silica gel) and micro‐HPLC with Chiralpak ID‐3 (0.30 mm ID × 150 mm, 3 µm silica gel) was conducted. Pharmaceutical racemates of 12 pharmacological classes, namely, α‐ and...
The osmium‐catalyzed oxyamination of chiral acyclic allylic alcohol derivatives bearing mono‐ and 1,1‐di‐substituted double bonds with benzyl N‐(4‐tosyloxy)carbamate proceeds with high regioselectivity and moderate levels of diastereoselectivity favoring the anti product. The observed stereoselectivity shows a clear and systematic trend with anti:syn ratios increasing in line with the size of substituent...
The concentration sensitivity of a racemic drug (chlorpheniramine maleate) in chiral capillary electrophoresis with electrospray ionization – mass spectrometric detection was improved ~500‐fold via stacking. Enantiomeric separation was achieved through the use of a neutral chiral pseudostationary phase (2‐hydroxpropyl‐β‐cyclodextrin), untreated fused‐silica capillaries, and the application of a partial‐filling...
Chiral comprehensive two‐dimensional gas chromatography (eGC×GC) coupled to quadrupole–accurate mass time‐of‐flight mass spectrometry (QTOFMS) was evaluated for its capability to report the chiral composition of several monoterpenes, namely, α‐pinene, β‐pinene, and limonene in cardamom oil. Enantiomers in a standard mixture were fully resolved by direct enantiomeric‐GC analysis with a 2,3‐di‐O‐methyl‐6‐...
This review brings together the past and current methods for synthesizing the classical cucurbit[n]uril (Q[n]), structural variants, and derivatives. Here we refer to the first family of Q[n] as " classical," where the cavity is spheroidal and carry no substituents at any of the equatorial methine carbons or the methylene bridging carbons. The synthetic background and general physical and...
Ibuprofen and naproxen are commonly used members of a class of pharmaceuticals known as 2‐arylpropionic acids (2‐APAs). Both are chiral chemicals and can exist as either of two (R)‐ and (S)‐enantiomers. Enantioselective analyses of effluents from municipal wastewater treatment plants (WWTPs) and from untreated sewage overflow reveal distinctly different enantiomeric fractions for both pharmaceuticals...
Nanoparticles are molecular‐sized solids with at least one dimension measuring between 1–100 nm or 10–1000 nm depending on the individual discipline's perspective. They are aggregates of anywhere from a few hundreds to tens of thousands of atoms which render them larger than molecules but smaller than bulk solids. Consequently, they frequently exhibit physical and chemical properties somewhere between...
New affinity monolithic capillary columns of 150 µm internal diameter were prepared in situ fused glass capillary via either immobilization or encapsulation of Candida antarctica lipase B (CALB) on or within polymer monoliths, respectively. The immobilized lipase‐based monoliths were prepared via copolymerization of 19.1% monomers (8.9% MMA and 10.2% GMA), 19.8% EDMA, and 61.1% porogens (54.2% formamide...
A new series of dirhodium(II) tetracarboxylate was derived from N‐1,2‐naphthaloyl‐(S)‐amino acid ligands. In terms of enantioselectivity, Rh2(S‐1,2‐NTTL)4 (3a) derived from N‐1,2‐naphthaloyl‐(S)‐tert‐leucine, was the best‐performing catalyst among the new series in the enantioselective synthesis of cyclopropylphosphonate derivatives (up to >99% enantiomeric excess). A predictive model was proposed...
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